Living LFS is working to promote research opportunities for our families with LFS. A new study that is currently enrolling is called the Li-Fraumeni & TP53: Understanding & Progress (LiFT UP) study. This study is funded by the National Institutes of Health/National Cancer Institute in collaboration with Dana-Farber Cancer Institute, City of Hope, and Baylor College of Medicine.
Any person with a TP53 mutation is eligible to participate in this study! One of the main purposes of this study is to gain a better understanding of cancer risks associated with TP53 mutations. Clinicians are often faced with the challenge of predicting cancer risks, as more people are identified to carry TP53 mutations who may not have family histories of cancer that appear as “typical” LFS families. Another main goal of this study is to understand which people have a TP53 mutation identified on their genetic testing, but who do not have LFS.
Clinicians and patients can work together to advance our knowledge of TP53 and LFS. The participation in LiFT UP will not exclude people from participating in other LFS research studies. Participation includes:
- Sharing your medical records related to your TP53 genetic test and any cancer history
- Providing a blood, saliva sample, and some eyebrow hairs
- Allowing us to obtain any stored tissue samples from prior biopsies or surgeries
- Answering short questionnaires periodically
As many of you know, LFS affects the family as well. The study team strongly encourages family participation in this study to learn more about TP53 mutations within a family. Please share this study information with your relatives so they may get involved!
The LiFT UP study website at liftupstudy.org has more information about this study and details about participation. A contact form is available on the website for you to complete if you wish to participate.
